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Research
Structure of vitamin B12 (cobalamin)and benzimidazole, purine, and phenolic derivatives that are found as lower ligands in B12 and other cobamides in the natural world with production and utilization across kingdoms
Vitamin B12, a member of the cobamide family of tetrapyrrolic cofactors, is a
vital nutrient for humans involved in key metabolic activities. The biosynthesis
of B12 and related cobamide cofactors employs enzymes with fascinating
features like multisubstrate activity, regioselectivity, and novel reaction
mechanisms.
I Study these enzymes in depth to enable us to understand the
biochemistry involved in the synthesis of such important structurally diverse
cofactors.
The exploration of these enzymes will open new avenues in understanding the biochemistry of cofactors and other biomolecules with slight structural variations.
Key enzymes of B12 biosynthesis under focus and snapshot of B12 and cobamides purification in our lab.
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